发明名称 METHODS FOR TREATING VIRAL INFECTION USING IL-28 AND IL-29 CYSTEINE MUTANTS
摘要 IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
申请公布号 US2009263352(A1) 申请公布日期 2009.10.22
申请号 US20090470336 申请日期 2009.05.21
申请人 ZYMOGENETICS, LLC 发明人 KLUCHER KEVIN M.;KINDSVOGEL WAYNE R.;SIVAKUMAR PALLAVUR V.;HENDERSON KATHERINE E.
分类号 A61K38/20;A61K38/21;A61K38/57;A61K39/12;A61K39/21;A61K39/29;A61P31/12;C07K14/54 主分类号 A61K38/20
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