POLYMORPHS OF HYDROCHLORIDE SALT 05-(3-(ETHYLSULFONYL)PHENYL)-3,8-DIMETHYL-N-(1-METHYLPIPERIDIN-4-YL)-9H-PYRIDO[2,3-B] INDOLE-7-CARBOXAMIDE AND METHODS OF USE THEREFOR

摘要

Polymorphic forms of the hydrochloride salt of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1 -methyIpiperidin-4-yl)-9h-pyrido[2,3-b]indole-7-carboxamide (referred to herein as Compound 1) which has the formula: and compositions thereof, wherein the Compound 1 is present in one or more polymorphic forms. Also provided are novel methods for the preparation of the polymorphs of Compound 1, and kits and articles of manufacture of the compositions, and methods of using the compositions to treat a disease state for which a kinase possesses activity that contributes to the pathology selected from the group consisting of cancer, dementia related diseases and arthritis.