COMPOSITIONS OF PAPILLOMAVIRUS PROTEINS AND METHODS OF USE

摘要

Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one papillomavirus protein, such as a papillomavirus suppressor binding protein, papillomavirus transforming protein and papillomavirus capsid protein, can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. The Toll-like Receptor 5 agonist and papillomavirus protein can be components of a fusion protein, can be associated with at least one particle in a molar ratio no greater than about 1 and can be administered to subjects in relatively low doses.