| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a compound having the inhibitory effect of thyrosine kinase activity such as EGFR, VEGFR2, etc., and useful as an antitumor agent. Ž<P>SOLUTION: This boron-containing quinazoline derivative expressed by formula (I) [wherein, R<SP>1</SP>, R<SP>2</SP>are each H, an alkoxy, -O-(CH<SB>2</SB>)<SB>n</SB>-OCH<SB>3</SB>, -X-B-(OR<SP>6</SP>)(OR<SP>7</SP>) or the like; R<SP>3</SP>, R<SP>4</SP>are each H, an alkyl, a haloalkyl, an alkoxy or a halogen atom; R<SP>5</SP>is H or -B(OR<SP>8</SP>)(OR<SP>9</SP>); D is -O- or -NH-; provided that when the R<SP>5</SP>is H, one of the R<SP>1</SP>, R<SP>2</SP>is -B(OR<SP>6</SP>)(OR<SP>7</SP>), and when the R<SP>5</SP>is -B(OR<SP>8</SP>)(OR<SP>9</SP>), the R<SP>5</SP>bonds at a meta position or a para position relative to the linking group D] or its pharmaceutically acceptable salt is provided. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
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