发明名称 |
Amide Derivatives and Pharmaceutical Use Thereof |
摘要 |
The use of substituted amides for modulating the activity of 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11betaHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.
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申请公布号 |
US2009264414(A1) |
申请公布日期 |
2009.10.22 |
申请号 |
US20090493698 |
申请日期 |
2009.06.29 |
申请人 |
HIGH POINT PHARMACEUTICALS, LLC |
发明人 |
ANDERSEN HENRIK SUNE;KAMPEN GITA CAMILLA TEJLGAARD;CHRISTENSEN INGE THOGER;MOGENSEN JOHN PATRICK;LARSEN ANNETTE ROSENDAL;KILBURN JOHN PAUL |
分类号 |
A61K31/55;A61K31/16;A61K31/166;A61K31/357;A61K31/403;A61K31/404;A61K31/415;A61K31/4155;A61K31/416;A61K31/4184;A61K31/437;A61K31/4468;A61K31/5377;A61K45/06;A61P3/04;A61P3/10;C07C233/65;C07D209/04;C07D211/56;C07D223/04;C07D231/14;C07D235/04;C07D403/06;C07D413/12;C07D471/04;C07D487/08;C07D493/04 |
主分类号 |
A61K31/55 |
代理机构 |
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