发明名称 |
ANTIBODY SPECIFICITY TRANSFER USING MINIMAL ESSENTIAL BINDING DETERMINANTS |
摘要 |
The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal essential binding specificity determinant from a heavy chain or light chain CDR3 from the reference antibody. The method can be used, e.g., in humanization procedures. The invention also provides libraries and antibodies made in accordance with the methods. |
申请公布号 |
EP1761561(A4) |
申请公布日期 |
2009.10.21 |
申请号 |
EP20050711847 |
申请日期 |
2005.01.20 |
申请人 |
KALOBIOS INC. |
发明人 |
FLYNN, PETER;LUEHRSEN, KENNETH;BALINT, ROBERT, F.;HER, JENG-HORNG;BEBBINGTON, CHRISTOPHER, R.;YARRANTON, GEOFFREY, T. |
分类号 |
G01N33/53;C07K16/00;C07K16/12;C07K16/44;C12N5/06;C12N15/09;C12P21/06;C12Q1/70 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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