METHOD FOR PRODUCTION OF OPTICALLY ACTIVE BIPHENYLALANINE COMPOUND OR SALT OR ESTER THEREOF

摘要

Disclosed is a method for production of an optically active biphenylalanine compound represented by the formula (2) :
(wherein, R 2 is a protective group of an amino group, and R 3 and R 4 are each independently a hydrogen atom, etc.)
or a salt thereof and an optically active biphenylalanine ester compound represented by the formula (3):
(wherein, R 1 is an alkyl group, etc.)
wherein the method comprises hydrolyzing a biphenylalanine ester compound represented by the formula (1):
with a protease produced by a microorganism belonging to Bacillus sp. in the presence of at least one alkali selected from an alkali metal hydroxide and an alkaline earth metal hydroxide.