发明名称 |
PROTECTIVE AGENT FOR RETINAL NERVE OR OPTIC NERVE |
摘要 |
The present invention provides a protective agent for retinal nerve or optic nerve which exerts its effect through a different mechanism from that of conventional therapeutic agents and can be taken for long periods. The present invention is the protective agent for retinal nerve or optic nerve which comprises a compound with aldose reductase inhibiting activity such as the compound represented by the following general formula as an active ingredient. A preferable compound thereof is (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide:
wherein X represents a halogen atom or a hydrogen atom, R1 and R2 independently represent a hydrogen atom or an optionally substituted C1 to C6 alkyl group, or R 1 and R 2 , together with a nitrogen atom bound thereto, or optionally another nitrogen atom or an oxygen atom, are combined to form a 5- to 6-membered heterocycle.
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申请公布号 |
EP2110141(A1) |
申请公布日期 |
2009.10.21 |
申请号 |
EP20080704120 |
申请日期 |
2008.01.30 |
申请人 |
SANWA KAGAKU KENKYUSHO CO., LTD |
发明人 |
CHUNG, SOOKJA, KIM;CHUNG, STEPHEN;HIBI, CHIHIRO |
分类号 |
A61K31/198;A61K31/407;A61K31/41;A61K31/4166;A61K31/4184;A61K31/4188;A61K31/425;A61K31/50;A61K31/501;A61K31/517;A61K31/5415;A61K45/00;A61P9/00;A61P25/02;A61P27/02;A61P27/06;A61P43/00;C07D491/107 |
主分类号 |
A61K31/198 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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