SEMI-SYNTHETIC TAXANES WITH ANTITUMOR AND ANTIANGIOGENETIC ACTIVITIES

摘要

Novel derivatives obtained by oxidation, stereospecific reduction and esterification of baccatine III and the use thereof as antitumor, antiangiogenetic and anti-arthrosis agents. The compounds of t he invention have cytotoxicity comparable to that of other taxanes but lower systemic toxicity and they can be administered intravenously or orally.