| 摘要 |
Biodegradable controlled release systems providing prolonged controlled release of drugs, and methods for the manufacture thereof are disclosed. The systems are formed from a biocompatible, biodegradable polymer, in particula r poly-4-hydroxybutyrate (PHA4400) or copolymers thereof. Copolymers of 4- hydroxybutyrate include but are not limited to poly-3-hydroxybutyrate-co-4- hydroxybutyrate (PHA3444), and poly-4-hydoxybutyrate-co-glycolate (PHA4422). Drugs are generally incorporated into the polymer using a method that yields a uniform dispersion. The type of drug and the quantity are selected based on the known pharmaceutical properties of these compounds. The systems may be administered for example by implantation, injection, topical administration, or oral ingestion. They may also be used in combination with a medical devic e, for example, a stent. A major advantage of the drug delivery system is that it does not need to be removed after use since it is slowly degraded and cleare d by the patient's body. The device has desirable physical properties, includi ng strength, modulus and elongation.
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