An anti-HIV vaccine composition is disclosed. The vaccine comprises an combination of immunogenic peptide mixtures, which mixtures may be prepared in a single synthesis. The composition collectively represents the in vivo variability seen in immunogenic epitopes from highly variable regions of HIV. Immunization with the vaccine elicits broadl y reactive immunity (CTL and T helper cell responses) against the divergent strains of HIV upon which it is based. The vaccine may be formulated to target regionally distinct variability based on an HIV clade predominant in a geographical region.
申请公布号
CA2540279(C)
申请公布日期
2009.10.20
申请号
CA20062540279
申请日期
2006.02.28
申请人
VARIATION BIOTECHNOLOGIES INC.
发明人
TORRES, JOSE VIDAL;ANDERSON, DAVID EVANDER;DIAZ-MITOMA, FRANCISCO J.