A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular conformation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed.
申请公布号
WO2009081136(A3)
申请公布日期
2009.10.15
申请号
WO2008GB04223
申请日期
2008.12.19
申请人
HEPTARES THERAPEUTICS LIMITED;WEIR, MALCOLM, PETER;MARSHALL, FIONA, HAMILTON