METHOD FOR DESOLVATING SOLVATE OF ATORVASTATIN HEMI-CALCIUM, AND ATORVASTATIN HEMI-CALCIUM ESSENTIALLY FREE OF ORGANIC SOLVENT

摘要

PROBLEM TO BE SOLVED: To provide a method for removing an organic solvent from crystals of atorvastatin hemi-calcium containing the organic solvent. SOLUTION: In one process, an organic solvent is displaced by vapor diffusion of water in a vessel maintained at elevated humidity. In another process, an organic solvent is removed by fluidized bed drying. The invention further provides atorvastatin hemi-calcium containing a 1% or less organic solvent which can be obtained from atorvastatin hemi-calcium that is crystallized from an organic solvent-containing solution by practice of the above processes. COPYRIGHT: (C)2010,JPO&INPIT