MODIFIED CHAPERONIN 10 AND PRR SIGNALING

摘要

The present invention relates to an isolated Cpn10 polypeptide possessing an increased affinity for a PRR ligand compared to a wild-type Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.