<p>The invention relates to identification of a cis-acting diversification activator (DIVAC) that is necessary and sufficient for the activation of diversification in transcription units linked thereto. The invention provides a method for diversification of a target nucleic acid comprising introducing a genetic construct comprising the diversification activator into a recipient cell, wherein the diversification activator is linked to the target nucleic acid.</p>
申请公布号
WO2009124777(A1)
申请公布日期
2009.10.15
申请号
WO2009EP02680
申请日期
2009.04.09
申请人
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT (GMBH);BUERSTEDDE, JEAN-MARIE;CALDWELL, RANDOLPH, B.