DÉRIVÉS DE LACTONES DE DITERPÈNES DE<i

摘要

The invention discloses Tripterygium wilfordii diterpene lactone derivatives represented by formula (1), their optical isomers and pharmaceutically acceptable salts and hydrates. The invention also provides pharmaceutical compositions and preparations comprising therapeutically effective Tripterygium wilfordii diterpene lactone derivatives represented by formula (1), their optical isomers and pharmaceutically acceptable salts and hydrates, and conventional pharmaceutical auxiliaries. The invention also discloses the application of the pharmaceutical compositions. The invention screens Tripterygium wilfordii diterpene lactone derivatives with good effect and low toxicity and makes them use in preparing medicaments for treating tumor diseases. The pharmaceutical compositions can be formulated to preparations in favor of the absorption by warm blood's tissues and apparatuses and have good application foreground in treating proliferative diseases such as tumors and so on.