发明名称 |
MAT II SUBUNIT RNAI AND THERAPEUTIC METHODS USING SAME |
摘要 |
<p>The presently disclosed subject matter generally relates to methods and compositions for modulating MAT Il activity. More particularly, the presently disclosed subject matter relates to methods and compositions for inhibiting the expression of MAT Il ß subunit in a subject via RNAi by administering siRNA or shRNA molecules directed to MAT Il ß subunit. In some embodiments, the methods and compositions of the presently disclosed subject matter generally relates to the treatment of cancer. More particularly, the methods and compositions of the presently disclosed subject matter relates to the inhibition of MAT Il ß subunit for the treatment of leukemia.</p> |
申请公布号 |
WO2009126651(A2) |
申请公布日期 |
2009.10.15 |
申请号 |
WO2009US39809 |
申请日期 |
2009.04.07 |
申请人 |
KOTB, MALAK;GELLER, ARTHUR, M. |
发明人 |
KOTB, MALAK;GELLER, ARTHUR, M. |
分类号 |
C12N15/63;A61K48/00;A61P35/02;C07H21/02;C12N15/11;C12N15/113;C12N15/115 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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