MESOTHELIOMA-SPECIFIC PROMOTER AND USE THEREOF

摘要

Disclosed is a promoter which has a transcriptional activity specific to mesothelioma and exhibits a low transcriptional activity on other cancer cells and normal cells including a mesothelium. Also disclosed is use of the promoter, specifically a vector for use in gene therapy or a therapeutic agent for mesothelioma, which comprises the promoter. Specifically disclosed is a promoter derived from a gene of CRI1 which is one of the markers for mesothelioma. Also specifically disclosed is a vector having a cell death-inducing gene or a cell lysis-inducing gene as a transgene and carrying a promoter derived from CRI1 gene upstream from the transgene. By using the vector, it becomes possible to elicit a cell death- or cell lysis-inducing activity in a mesothelioma-specific manner. Each of the vector for use in gene therapy and the therapeutic agent for mesothelioma comprises a viral vector carrying the promoter derived from CRI1 gene.