发明名称 |
KOMBINIERTE IMPFSTOFFE, DIE HEPATITIS B OBERFLÄCHE ANTIGEN UND ANDERE ANTIGENEN ENTHALTEN |
摘要 |
<p>Stable and effective multivalent vaccine compositions comprising Hepatitis B surface antigen (HBsAg) are described wherein the HBsAg component is stable for one week at 37° C and is highly immunogenic, for example when the vaccine is administered to infants. The compositions typically comprise HBsAg adsorbed to aluminium phosphate and other antigens, especially those suitable for use in a paediatric vaccine, adsorbed to aluminium phosphate or aluminium hydroxide. Methods for preparing the vaccines and the use of aluminium phosphate to stabilise HBsAg in a multivalent vaccine formulation are also described.</p> |
申请公布号 |
AT444079(T) |
申请公布日期 |
2009.10.15 |
申请号 |
AT19970204034T |
申请日期 |
1993.05.15 |
申请人 |
GLAXOSMITHKLINE BIOLOGICALS S.A. |
发明人 |
PETRE, JEAN;HAUSER, PIERRE |
分类号 |
A61K39/295;A61K;A61K39/05;A61K39/08;A61K39/10;A61K39/102;A61K39/116;A61K39/13;A61K39/29;A61K39/385;A61K39/39;A61K47/02;A61K47/48;A61P31/12 |
主分类号 |
A61K39/295 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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