INHIBITORS OF BACTERIAL NITRIC OXIDE SYNTHASE, AND RELATED SCREENING METHODS
摘要
The invention relates in part to compounds that act as highly nitric oxide (NO)- specific turn-on fluorescent probes. The present invention also relates to the use of these fluorescein-based sensors to screen selectively for inhibitors of bacterial nitric oxide synthase (bNOS). Compounds of the present invention readily detect nitric oxide produced in vivo. Therefore, they can be used in an assay that measures NO production by bNOS. Using a sensor of the invention one can screen libraries of small molecules for inhibitors of bNOS.
申请公布号
WO2009079549(A3)
申请公布日期
2009.10.15
申请号
WO2008US87137
申请日期
2008.12.17
申请人
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;LIPPARD, STEPHEN, J.;MCQUADE, LINDSEY, E.;NUDLER, EVGENY, A.
发明人
LIPPARD, STEPHEN, J.;MCQUADE, LINDSEY, E.;NUDLER, EVGENY, A.