发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Nav1.8 GENE |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less than 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene in a cell.
|
申请公布号 |
US2009258934(A1) |
申请公布日期 |
2009.10.15 |
申请号 |
US20090487605 |
申请日期 |
2009.06.18 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
SAH DINAH;FRANK-KAMENETSKY MARIA;GEICK ANKE;HADWIGER PHILIPP;ROEHL INGO;TAN PAMELA;VORNLOCHER HANS-PETER |
分类号 |
A61K31/713;A61P25/00;C07H21/02;C12N5/10;C12N15/113;C12N15/63 |
主分类号 |
A61K31/713 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|