发明名称 |
METHODS AND COMPOSITIONS FOR ACCELERATING THE GENERATION OF REGULATORY T CELLS EX VIVO |
摘要 |
The present invention is directed to generating regulatory T cells by treating a cell culture that includes non-regulatory T cells with a regulatory composition. The invention encompasses methods utilizing a regulatory composition that includes agents that prevent methylation of the locus for the FOXP3 transcription factor, agents that accelerate differentiation of T cells into suppressor cells, and agents that are histone deacetylase inhibitors. The invention also encompasses compositions of regulatory T cells generated by culturing non-regulatory T cells with a regulatory composition as well as the use of such regulatory T cells in the treatment of autoimmune diseases and aberrant immune responses.
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申请公布号 |
US2009257988(A1) |
申请公布日期 |
2009.10.15 |
申请号 |
US20090421941 |
申请日期 |
2009.04.10 |
申请人 |
USC STEVENS, HUGHES CENTER |
发明人 |
HORWITZ DAVID A.;GRAY J. DIXON |
分类号 |
A61K35/12;C12N5/02;C12N5/0783 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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