| 摘要 |
PROBLEM TO BE SOLVED: To provide a new breast cancer diagnostic and therapeutic method of using protein as a molecule marker, by quantitatively identifying protein singularly or very excessively developed in a breast cancer cell line and protein indicating increased expression and reduced expression. SOLUTION: This breast cancer diagnostic method is characterized by diagnosing breast cancer by using specific protein varied in the expression in a human breast cancer cell line identified by proteome analysis as the molecule marker, by using a fluorescent derivatization-liquid chromatography tandem mass spectrometry (FD-LC-MS/MS). The breast cancer diagnostic method is characterized by diagnosing the breast cancer by using galectin-1 and annexin-2 or thiodrexin-1, or annexin-2 and EF-TU, or peroxiredoxin-1 and RanGAP as the molecule marker and using a pair of galectin-1 and/or annexin-2 and tropomyosin-1 as the molecule marker. This invention can provide the new breast cancer diagnostic and therapeutic method. COPYRIGHT: (C)2010,JPO&INPIT
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