发明名称 |
BIODEGRADABLE, ANIONIC POLYMERS DERIVED FROM THE AMINO ACID L-TYROSINE |
摘要 |
A polymer with a hydrolytically la-bile backbone and having structure (VIII) wherein R9 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid group or the benzyl ester thereof; R12 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid ester group selected from straight and branched alkyl and alkylaryl esters con-taining up to 18 carbon atoms and ester derivatives of biologically and pharma-ceutically active compounds covalently bonded thereto, provided that the ester group is not a benzyl group or a group that is removed by hydrogenolysis; each R7 is independently an alkylene group containing up to four carbon atoms; A is selected from: (a) and (b) wherein R8 is selected from saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms; k is between about 5 and about 3,000; and x and f independently range from zero to less than one.
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申请公布号 |
CA2309278(C) |
申请公布日期 |
2009.10.13 |
申请号 |
CA19982309278 |
申请日期 |
1998.11.07 |
申请人 |
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY |
发明人 |
KOHN, JOACHIM B.;GUAN, SHUIYUN;ERTEL, SYLVIE I.;KEMNITZER, JOHN E.;BRODE, GEORGE L.;BOLIKAL, DURGADAS |
分类号 |
C08G64/06;C08G81/00;A61K9/20;A61K38/00;A61K47/34;A61L17/10;A61L27/18;A61L27/34;A61L27/54;A61L27/58;A61L31/06;A61L31/10;A61L31/14;A61L31/16;C07K14/00;C08G63/672;C08G63/685;C08G64/00;C08G64/04;C08G64/12;C08G64/16;C08G64/18;C08G64/42;C08G69/10;C08G69/44;C08G69/48;C08L101/16 |
主分类号 |
C08G64/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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