New method for selecting compounds useful for treating and/or preventing microbial Shigella infection

摘要

The present invention provides a method for the selection of compounds, which permit to enhance the level of expression of a gene implicated in antimicrobial defence comprising the step of: a) contacting a test compound with an host cell expressing a reporter nucleic acid comprising a nucleic acid sequence coding for a reporter placed under the control of a promoter, which promoter comprises all or part of the promoter sequence of said gene implicated in antimicrobial defence, and b) measuring the level of expression of the reporter gene. The present invention further relate to new compounds identified by such method, and to pharmaceutical composition comprising such compounds, and the use of such compound for preventing and/or treating an microbial infection or for preventing and/or treating cancer in a subject.