摘要 |
[PROBLEMS] To provide a compound having an excellent JAK3-inhibiting activity and useful as an active ingredient for a therapeutic or prophylactic agent for various immune diseases including autoimmune diseases, inflammatory diseases and allergic diseases. [MEANS FOR SOLVING PROBLEMS] A study is made on a novel condensed heterocyclic derivative, and it is confirmed that the condensed pyridine compound of the invention has an excellent JAK3-inhibiting activity. It is confirmed that the compound is useful as an active ingredient for a therapeutic or prophylactic agent for a disease induced by undesirable cytokine signaling such as rejection upon living donor transplantation, an autoimmune disease, asthma, atopic dermatitis, rheumatism, psoriasis and atherosclerosis or a disease induced by abnormal cytokine signaling such as cancer and leukemia because of its inhibitory activity on JAK3.
|