| 摘要 |
In an implantable medical device and a method for the operation thereof, acoustic energy is sensed in a subject in whom the device is implanted, and signals indicative of heart sounds of the heart of the patient are produced over predetermined periods of a cardiac cycle, during successive cardiac cycles. A signal corresponding to the second heart sound (S2) is extracted from the sensed signal, and the respective durations of successive second heart sound signals are determined. An optimization procedure is implemented that includes controlling delivery of pacing pulses based on the determined durations of successive second heart sounds, to determined a combination of stimulation intervals, including at least the AV interval and the VV interval, that causes a substantially synchronized closure of the aortic and pulmonary valves.
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