发明名称 |
Process for the preparation of sorafenib and salts thereof |
摘要 |
Methods for the synthesis of the N-carbamoyl imidazole (I) and its 1:1 adduct with imidazole are provided. Methods for the preparation of these crystalline intermediates in a high state of purity are also provided. These intermediates react cleanly under mild conditions to produce sorafenib in high yield and purity, without generating difficult-to-remove impurities.
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申请公布号 |
US2009253913(A1) |
申请公布日期 |
2009.10.08 |
申请号 |
US20090381000 |
申请日期 |
2009.03.05 |
申请人 |
ROSSETTO PIERLUIGI;MACDONALD PETER LINDSAY;CANAVESI AUGUSTO |
发明人 |
ROSSETTO PIERLUIGI;MACDONALD PETER LINDSAY;CANAVESI AUGUSTO |
分类号 |
C07D213/78;C07D233/14 |
主分类号 |
C07D213/78 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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