BIOSENSOR FOR ANALYTE DETECTION

摘要

This invention relates to biosensors for detecting analyte molecules, such as nucleic acids, in a sample solution. The biosensors comprise a capture electrode which has probe molecules immobilised at its surface which specifically bind to analyte molecules. The probe molecules are separated on the surface of the capture electrode by spacer molecules and the proportion of probe molecules to spacer molecules is less than 10%. Changes in the electrical properties of the capture electrode surface are indicative of the binding of the immobilised probe molecules to analyte molecules. Biosensors as described may be useful for example, in diagnostic, genomic and forensic applications.