| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for producing a virus-like particle of avian infectious bronchitis virus. Ž<P>SOLUTION: An infectious bronchitis virus-like particle is produced by transducing a plasmid DNA expressing a gene encoding a spike protein of avian infectious bronchitis virus, a gene encoding an envelop protein, a gene encoding a membrane protein and a gene encoding a nucleocapsid protein into a eukaryotic cell, culturing the cell and recovering the object particle from the culture supernatant fluid. Since the virus-like particle is not virus, it is expected to have a function as a safe recombinant component vaccine absolutely free from the risk of producing the disease in chicken. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
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