发明名称 |
Use of alcohol co-solvents to improve pegylation reaction yields |
摘要 |
Disclosed is a method of producing a composition of matter. The method involves obtaining a pharmacologically active peptide; and conjugating the peptide to a pharmaceutically acceptable polyethylene glycol (PEG) by reacting the peptide with a PEG-aldehyde compound at a free amine moiety on the peptide in a buffer solution comprising an alcohol co-solvent. |
申请公布号 |
US2009252703(A1) |
申请公布日期 |
2009.10.08 |
申请号 |
US20070974472 |
申请日期 |
2007.10.12 |
申请人 |
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发明人 |
GEGG, JR. COLIN V.;D'AMICO DERIN C.;WRIGHT MARIE E. |
分类号 |
A61K38/17;A61K38/20;A61K38/28 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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