发明名称 |
PROTEASE SCREENING METHODS AND PROTEASES IDENTIFIED THEREBY |
摘要 |
<p>Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macro globulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.</p> |
申请公布号 |
WO2008045148(A8) |
申请公布日期 |
2009.10.08 |
申请号 |
WO2007US15571 |
申请日期 |
2007.07.05 |
申请人 |
CATALYST BIOSCIENCES, INC.;TORREY PINES INSTITUTE FOR MOLECULAR STUDIES;MADISON, EDWIN, L. |
发明人 |
MADISON, EDWIN, L. |
分类号 |
C12N9/64;C12N9/50;C12N15/10 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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