OLIGOMERIC COMPOUNDS COMPRISING BICYCLIC NUCLEOSIDES AND HAVING REDUCED TOXICITY
摘要
In certain embodiments, the present invention provides oligomeric compounds having favorable toxicity profiles and therapeutic indexes. Compounds of the present invention comprise bicyclic nucleosides. Certain such bicyclic nucleosides are pyrimidines that do not include a methyl group at the 5-carbon. Oligomeric compounds comprising such nucleosides are less toxic than compounds comprising bicyclic nucleosides that do include a methyl group at the 5-carbon. In certain embodiments, the present invention provides methods of preparing and using such compounds.
申请公布号
WO2009124295(A2)
申请公布日期
2009.10.08
申请号
WO2009US39557
申请日期
2009.04.03
申请人
ISIS PHARMACEUTICALS, INC.;SWAYZE, ERIC, E.;SIWKOWSKI, ANDREW, M.