发明名称 |
SELECTIVE SUBSTRATES FOR MATRIX METALLOPROTEINASES |
摘要 |
The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetics. The selective substrate polypeptides contain the following sequences: MMP-2 selective substrate polypeptides contain SEQ ID NOS:1-27, MMP-9 selective substrate polypeptides contain SEQ ID NOS:28-35, and MT1-MMP selective substrate polypeptide contain SEQ ID NOS:36-40. In addition, the invention provides a method of preferentially directing a moiety to a site of MMP-2 activity by administering to a subject an effective amount of an isolated MMP-2 selective substrate polypeptide containing SEQ ID NOS:45-47 linked to a moiety. Also provided is a method of preferentially directing a moiety to a site of MMP-9 activity by administering to a subject an effective amount of an isolated MMP-9 selective substrate polypeptide containing SEQ ID NO:44 linked to a moiety, and preferentially directing a moiety to a site of MT1-MMP activity by administering to a subject an effective amount of an isolated MT1-MMP selective substrate polypeptide containing SEQ ID NOS:36-40 linked to a moiety.
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申请公布号 |
US2009253896(A1) |
申请公布日期 |
2009.10.08 |
申请号 |
US20080252160 |
申请日期 |
2008.10.15 |
申请人 |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH |
发明人 |
SMITH JEFFREY W.;CHEN EMILY I.;KRIDEL STEVEN J. |
分类号 |
C07K7/06;A61K47/48;A61K49/00;C07K5/083;C07K5/087;C07K5/09;C07K5/097;C07K5/10;C07K5/103;C07K5/11;C07K5/117;C07K7/08;C12Q1/37 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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