METHOD OF PRODUCING (S)-3-(1-CYANO-1,1-DIPHENYLMETHYL)-PYRROLIDINE

摘要

A method of producing (S)-3-(1-cyano-1,1-diphenylmethyl)-pyrrolidine which comprises reacting an (S)-1-protected-3-(sulfonyloxy)-pyrrolidine having an easily deprotectable protecting group with diphenylacetonitrile in the presence of a base to give an (S)-1-protected-3-(1-cyano-1,1-diphenylmethyl)-pyrrolidine and then deprotecting the obtained product under mild conditions. According to the above-described method, it is possible to efficiently produce (S)-3-(1-cyano-1,1-diphenylmethyl)-pyrrolidine which is an important intermediate in the process of producing a muscarinic receptor antagonist (darifenacin).