HEPATITIS B VARIANTS WITH REDUCED SENSITIVITY TO THERAPEUTIC COMPOUNDS, THEIR DETECTION AND USES THEREOF

摘要

The present invention is a diagnostic kit and materials for: 1) the prediction of the long-term response of a chronic hepatitis B virus (HBV) carrier to treatment with nucleoside/nucleotide analogue, or their combination; 2) the detection of HBV variants that exhibit reduced reactivity to antibody detection; 3) the detection of HBV variants in the precore/core region that negatively affect the course of liver disease; 4) the identification of the HBV genotype.