发明名称 |
SOLID STATE FORMS OF A PHARMACEUTICAL |
摘要 |
The invention provides and describes solid state 17a-ethynyl-androst- 5-ene-3ß,7ß,17ß-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17a-ethynyl-androst-5- ene-3ß,7ß,17ß-triol include Form I anhydrate and Form IV and Form V solvates. The invention further relates to solid and suspension formulations containing 17a-ethynyl-androst-5-ene-3ß,7ß,17ß-triol in a described solid state form and use of the formulations to treat hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, and autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17a-ethynyl-androst-5-ene-3ß,7ß,17ß-triol and uses of such formulations in treating the described conditions. |
申请公布号 |
WO2009124300(A2) |
申请公布日期 |
2009.10.08 |
申请号 |
WO2009US39567 |
申请日期 |
2009.04.03 |
申请人 |
HOLLIS-EDEN PHARMACEUTICALS, INC.;WHITE, STEVEN, K.;IVANISEVIC, IGOR;STEPHENS, KYLE;ANDRES, MARK;WOLF, BRENTON |
发明人 |
WHITE, STEVEN, K.;IVANISEVIC, IGOR;STEPHENS, KYLE;ANDRES, MARK;WOLF, BRENTON |
分类号 |
A61K31/567;A61P9/10;A61P25/28;C07J5/00 |
主分类号 |
A61K31/567 |
代理机构 |
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地址 |
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