发明名称 |
NANOPARTICLE-MEDIATED SIGNAL AMPLIFICATION |
摘要 |
There is described a new class or type of initiators for polymerization as a means of signal enhancement, nanoparticle initiators, and methods for amplifying signal resulting from recognition events, thereby enhancing the detection of those recognition events. Methods include amplification achieved through polymerization using a nanoparticle initiator conjugated recognition element that is not consumed during the reaction. The polymer formed as a result of the absorption of light by the nanoparticle initiator and introduction of reactive species into a surrounding polymerizable monomer solution occurs in a spatially-limited region directly surrounding the nanoparticle initiator and is indicative of the recognition event(s). In one embodiment, a semiconductor quantum dot nanoparticle initiator is utilized. In another embodiment, a metal nanoparticle is utilized. In another embodiment, the signal is detected without instrumentation. In yet another embodiment, the signal is detected via a transmission-based instrument which captures an image of the formed polymer. |
申请公布号 |
WO2009120557(A2) |
申请公布日期 |
2009.10.01 |
申请号 |
WO2009US37564 |
申请日期 |
2009.03.18 |
申请人 |
INDEVR, INC.;ROWLEN, KATHY, L.;TAYLOR, AMBER, W. |
发明人 |
ROWLEN, KATHY, L.;TAYLOR, AMBER, W. |
分类号 |
C12Q1/68;B82B3/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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