ANTI-alphaVbeta3 RECOMBINANT HUMAN ANTIBODY, NUCLEIC ACID ENCODING THE SAME AND METHOD OF USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide an antibody specifically recognizing integrin αvβ3and inhibiting the functional activity thereof.

SOLUTION: The enhanced LM609 grafted antibodies exhibiting selective binding affinity to αvβ3, or a functional fragment thereof, are provided, wherein the enhanced LM609 grafted antibodies include CDR selected from the group consisting of VHCDR2; VHCDR3; and VLCDR1, represented by specific sequences. The antibody makes therapeutic treatment of integrin-mediated diseases possible.

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