ADAMANTINE DERIVATIVE FOR INHIBITING TOXICITY OF AMYLOID OLIGOMER

摘要

The present invention is a pharmaceutical composition containing a compound useful for inhibiting neurotoxicity caused by beta amyloid. The pharmaceutical composition of the present invention contains 1,3,5,7-tetrakis(aminomethyl) adamantine and homo compound, or salts thereof, as active ingredients. The inventors of the present invention have studied methods for reducing the toxicity of beta amyloid oligomers based on the formation mechanism of dodecamers in consideration of the fact that especially dodecamers from among beta amyloid oligomers exhibits a significant activity as a toxoid for synapses and neurons in cranial nerve diseases. The inventors of the present invention have confirmed that the compound of the present invention found from the study causes structural epitope degeneration of the dodecamer, reducing the toxicity of beta amyloid oligomers. The pharmaceutical composition containing the abovementioned compound is useful for preventing and treating cranial nerve diseases developed by the toxicity of beta amyloid oligomers, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, macular degeneration, prion disease, and the like.