发明名称 |
Monocarboxylates for modifying macrophage function |
摘要 |
The present invention is directed to methods of inhibiting the production of proinflammatory agents by macrophages by contacting the cells with a monocarboxylate such as nicotinic acid. The invention also includes methods of treating diseases that are associated with macrophage activation such as atherosclerosis; systemic lupus erythematosus; rheumatoid arthritis; inflammatory bowel disease; and diabetes mellitus.
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申请公布号 |
US2009247589(A1) |
申请公布日期 |
2009.10.01 |
申请号 |
US20070310971 |
申请日期 |
2007.09.12 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
ZANDI-NEJAD KAMBIZ;CHANDRAKER ANIL;BONVENTRE JOSEPH;MOUNT DAVID |
分类号 |
A61K31/455;A61P3/10;A61P37/06;C12N5/06 |
主分类号 |
A61K31/455 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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