发明名称 |
NOVEL STEROID 5-ALPHA-REDUCTASE |
摘要 |
The invention provides an isolated, novel steroid 5alpha-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a test compound and measuring the activity of the enzyme. A reduced activity relative to a control indicates that the test compound is an inhibitor of SRD5AIII. A method is also provided for detecting androgen stimulated prostate cancer or recurrent prostate cancer in an individual. The method comprises obtaining a prostate biopsy from an individual and determining the level of expression of SRD5AIII gene or protein relative to a normal control. An increased expression of SRD5AIII relative to the control is indicative of androgen stimulated prostate cancer or recurrent prostate cancer.
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申请公布号 |
US2009246785(A1) |
申请公布日期 |
2009.10.01 |
申请号 |
US20090404590 |
申请日期 |
2009.03.16 |
申请人 |
MOHLER JAMES L;TITUS MARK;KOZYREVA OLGA;FORD III O HARRIS;KAWINSKI ELSBIETA;LI YUN |
发明人 |
MOHLER JAMES L.;TITUS MARK;KOZYREVA OLGA;FORD, III O. HARRIS;KAWINSKI ELSBIETA;LI YUN |
分类号 |
C12Q1/68;C12Q1/26 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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