发明名称 |
Production and Use of Novel Peptide-Based Agents for Use with Bi-Specific Antibodies |
摘要 |
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a targetable conjugate. The targetable conjugate encompasses a hapten to which antibodies have been prepared. In preferred embodiments, the hapten is histamine-succinyl-glycine (HSG). In more preferred embodiments, the at least one arm comprises the CDR sequences of the HSG-binding 679 antibody. The targetable conjugate is attached to one or more therapeutic and/or diagnostic agents. The invention provides constructs and methods for producing the bispecific antibodies or antibody fragments, as well as methods for using them and kits comprising them.
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申请公布号 |
US2009246131(A1) |
申请公布日期 |
2009.10.01 |
申请号 |
US20090481233 |
申请日期 |
2009.06.09 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
HANSEN HANS J.;GRIFFITHS GARY L.;LEUNG SHUI-ON;MCBRIDE WILLIAM J.;QU ZHENGXING |
分类号 |
A61K51/10;G01R33/28;A61B5/055;A61K39/395;A61K47/42;A61K49/00;A61K51/00;A61K51/08;C07K5/107;C07K5/11;C07K16/18;C07K16/28;C07K16/30;C07K16/44;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/08;C12Q1/68;G01N33/50;G01N33/574;G01N33/577 |
主分类号 |
A61K51/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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