Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
申请公布号
ZA200707289(B)
申请公布日期
2009.09.30
申请号
ZA20070007289
申请日期
2007.08.28
申请人
GENTECH, INC.;ARRAY BIOPHARMA, INC.
发明人
LAIRD, ELLEN;WELCH, MIKE;HANSEN, JOSH;OLIVERO, ALAN;LYSSIKATOS, JOSEPH P.;GRINA, JONAS;NEWHOUSE, BRAD;TOPALOV, GEORGE