发明名称 |
IRTA-5 antibodies and their uses |
摘要 |
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-5 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-5, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma. |
申请公布号 |
ZA200608100(B) |
申请公布日期 |
2009.09.30 |
申请号 |
ZA20060008100 |
申请日期 |
2006.09.28 |
申请人 |
MEDAREX, INC. |
发明人 |
GRAZIANO, ROBERT;KEMPE, THOMAS;SRINIVASAN, MOHAN;CARDARELLI, JOSEPHINE M.;CUTTER, BETH |
分类号 |
A61K;A61K39/395;C07H;C07K16/28;C07K16/30;C12N |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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