发明名称 |
Interleuk-9 and interleukin-4 chimeric antagonist muteins and methods of using same |
摘要 |
Chimeric polypeptide antagonists that include an interleukin-4 (IL-4) mutein linked to an interleukin-9 (IL-9) mutein are provided, as are polynucleotides encoding the IL-4 and IL-9 chimeric mutein antagonists. Also provided are methods of using the chimeric mutein antagonists and encoding polypeptides to reduce or inhibit the responsiveness of a cell to a cytokine such as IL-4, IL-9 and/or interleukin-13. Methods using the compositions to treat disorders such as pulmonary disorders (e.g., asthma) also are provided. |
申请公布号 |
ZA200702529(B) |
申请公布日期 |
2009.09.30 |
申请号 |
ZA20070002529 |
申请日期 |
2005.09.21 |
申请人 |
AEROVANCE, INC. |
发明人 |
BOISVERT, DAVID C;LONGPHRE, MALINDA;WONG, TERESA M.;ZAREMBA, SYDNEY M. |
分类号 |
C07H;C07K;C12P |
主分类号 |
C07H |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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