Improved stabilizer cyanoacrylate formulations

摘要

A stabilized adhesive composition is provided including one or more polymerizable cyanoacrylate monomers, a first free radical stabilizer in a stabilization effective amount, and a second free radical stabilizer in a stabilization effective amount. The free radical stabilizers are selected to minimize mutagenicity in the composition and are used in amounts which provide adequate stabilization for long term storage while reducing disadvantageous effects of the free radical stabilizers. The stabilized adhesive composition further may include a first anionic stabilizer comprising a vapor phase anionic stabilizer and a second anionic stabilizer comprising a liquid phase anionic stabilizer. The stabilized adhesive composition may also include or be used with a polymerization initiator. Methods for the application of the stabilized adhesive compositions to living tissue are also provided.