发明名称 |
Stable pharmacological form of anticarcinogenic drug and method of obtaining such drug in that form |
摘要 |
The stable pharmaceutical form of the anti-cancer drug containing paclitaxel of the Fig. 1, according to the invention, is characterised in that it is a stable form of the active substance of a large surface, amorphous, possibly with some fine-crystalline additive. According to the invention, the method for production of the stable pharmaceutical form of the anticancer drug consists in dissolution of crystalline paclitaxel in a neutral organic solvent selected from the group comprising acetonitrile, dioxane, ethanol, or a mixture of those solvents, with possible addition of water, providing that the control of individual solvents in the mixture is in the range of 5 % to 95 %, while the content of water is in the range of 0 to 60 %; the resulting solution is possibly filtered, frozen, and solvents are removed by sublimation under reduced pressure, at a low temperature, and thereafter the preparation is possibly distributed into doses in conditions assuring its sterility. |
申请公布号 |
PL203300(B1) |
申请公布日期 |
2009.09.30 |
申请号 |
PL20000343615 |
申请日期 |
2000.10.31 |
申请人 |
WARSZAWSKIE ZAK&LSTROK,ADY FARMACEUTYCZNE POLFA SPO&LSTROK,KA AKCYJNA;INSTYTUT CHEMII ORGANICZNEJ PAN;AKADEMIA MEDYCZNA |
发明人 |
JANICKI STANIS&LSTROK,AW;SZNITOWSKA MA&LSTROK,GORZATA;KARA&SACUTE, W&LSTROK,ADYS&LSTROK,AW;MROCZEK ZDZIS&LSTROK,AW;TYRA&LSTROK,A ANDRZEJ;CZARNECKA IWONA |
分类号 |
A61K31/337;A61K9/19;A61K47/06;A61K47/10;A61K47/22;A61P35/00;C07D305/14 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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