| 摘要 |
The present invention relates to a method of enhancing cell homing and engraftment potential, the method comprises ex-vivo or in vitro subjecting a population of cells to an amount of nicotinamide for a period of time sufficient for enhancing cell homing and engraftment potential, the method is further characterized by at least one of the following:
(i) wherein said amount of nicotinamide and said period of time are selected sufficient to down regulate CD26 expression by cells of said population of cells but not for stem and/or progenitor cell expansion;
(ii) said population of cells does not include, mononuclear cells, early liver progenitor cells, committed progenitor cells, non-hematopoietic stem and progenitor cells, or embryonic stem and progenitor cells;
(iii) said subjecting is in the absence of nutrients;
(iv) said subjecting is in the absence of a cytokine;
(v) said subjecting is in the absence of FLT-3 ligand;
(vii) said subjecting is in the absence of stem cell factor (SCF);
(vii) said subjecting is in the absence of granulocyte colony stimulating factor (GCSF);
(viii) said subjecting is in the absence of an early acting cytokine; and
(ix) said subjecting is in the absence of a late acting cytokine;
and wherein said population of cells does not include a hematopoietic stem and/or progenitor cell population. |
