Modular scaffold for the design of specific molecules for the use as peptidomimetics and inhibitors of protein interaction

摘要

The invention relates to a modular scaffold for the design of specific molecules comprising oligomers of ²-amino acids with well defined secondary structural preferences, and the use of such compounds in biotechnology and pharmacy. The compounds according to the invention comprise two oligomers of disubstituted, heterochiral ²-amino acids which are linked by a turn inducing motive. They spontaneously form a hairpin-like structure with two opposing sides, with one substituent of each ²-amino acid pointing to one side of the structure, and the remaining substituent of each ²-amino acid pointing to the other. In order to stabilize the structure, the first group of substituents is modified in such a way that they form interacting pairs via intramolecular forces. By modification of the second group of substituents the compounds according to the invention are fit to mimic protein structures and to be used as peptidomimetics and/or inhibitors of protein interaction.